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Some people wonder if taking Progesterone cream is safer than using a hormone pill. Progesterone is a fat soluble cream that is easily absorbed in the skin. Applying it to the face, neck, inner arms, chest and the palm of hands are the best areas for the most effective results. When taking the pill form, most of the dose is lost in the liver. High doses can overload the liver and lead to other complicated health problems. Therefore, using the cream is best because the liver is not affected and the dosage is contained. Further instruction from your doctor will help you understand how your body is affected.